Product Description

Indications: Deltasone is indicated for the treatment of various inflammatory, allergic, autoimmune, endocrine, respiratory, dermatologic, hematologic, gastrointestinal, and edematous disorders. These include rheumatic disorders such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis, and post-traumatic osteoarthritis; endocrine disorders including adrenocortical insufficiency, congenital adrenal hyperplasia, thyroiditis, and hypercalcemia associated with cancer; dermatologic conditions such as pemphigus, severe psoriasis, exfoliative dermatitis, and erythema multiforme; allergic conditions including allergic rhinitis, bronchial asthma, atopic dermatitis, serum sickness, and drug hypersensitivity reactions; respiratory diseases like sarcoidosis, aspiration pneumonitis, and berylliosis; hematologic disorders including autoimmune hemolytic anemia and thrombocytopenia; nephrotic syndrome with proteinuria; and gastrointestinal diseases such as ulcerative colitis and regional enteritis.Pharmacology: Prednisolone is a synthetic corticosteroid with predominantly glucocorticoid activity. It suppresses inflammation by inhibiting phospholipase A2, thereby reducing the formation of inflammatory mediators such as prostaglandins and leukotrienes. Prednisolone is rapidly absorbed from the gastrointestinal tract, extensively protein-bound in plasma, metabolized mainly in the liver, and excreted through urine. Its plasma half-life ranges from 2 to 4 hours.Dosage & Administration:Adult Dosage:Nephrotic Syndrome: Initial dose is 2 mg/kg/day (maximum 80 mg/day) in divided doses 3-4 times daily until urine becomes protein-free for 3 consecutive days, followed by 1-1.5 mg/kg every other day for 4 weeks. Maintenance dose is 0.5-1 mg/kg every other day for 3-6 months.Anti-inflammatory Conditions: 5-60 mg daily in divided doses 1-4 times daily.Acute Asthma: 40-60 mg daily orally in a single dose or divided every 12 hours for 3-10 days.Allergic Conditions:Day 1: 10 mg before breakfast, 5 mg after lunch and dinner, and 10 mg at bedtime.Day 2: 5 mg before breakfast, lunch, and dinner, and 10 mg at bedtime.Day 3: 5 mg before breakfast, lunch, dinner, and bedtime.Day 4: 5 mg before breakfast, lunch, and bedtime.Day 5: 5 mg before breakfast and bedtime.Day 6: 5 mg before breakfast.Pediatric Dosage:Asthma:1 year: Acute 10 mg every 12 hours; maintenance 10 mg every other day.1-4 years: Acute 20 mg every 12 hours; maintenance 20 mg every other day.5-12 years: Acute 30 mg every 12 hours; maintenance 30 mg every other day.Above 12 years: Acute 40 mg every 12 hours; maintenance 40 mg every other day.Anti-inflammatory and Immunosuppressive Therapy: 0.05-2 mg/kg/day divided into 1-4 doses daily.Interaction: The effectiveness of Deltasone may be reduced by aminoglutethimide, antacids, barbiturates, carbamazepine, griseofulvin, mitotane, phenylbutazone, phenytoin, primidone, and rifampin. It may lower potassium levels, increasing the risk of arrhythmias with digitalis. Vaccinations and immunizations should be administered cautiously during corticosteroid therapy.Contraindications: Contraindicated in systemic fungal infections unless appropriate anti-infective therapy is used, hypersensitivity to Prednisolone or formulation components, and ocular herpes simplex due to risk of corneal perforation.Side Effects: Possible adverse effects include sodium and fluid retention, hypertension, potassium loss, muscle weakness, osteoporosis, fractures, peptic ulcer, pancreatitis, abdominal distension, impaired wound healing, skin thinning, petechiae, headache, vertigo, increased intracranial pressure, menstrual irregularities, Cushingoid features, growth suppression in children, cataracts, glaucoma, increased intraocular pressure, and negative nitrogen balance.Pregnancy & Lactation: Prednisolone should be used during pregnancy only when clearly necessary and when benefits outweigh potential fetal risks. Corticosteroids may pass into breast milk and could affect infant growth or adrenal function.Precautions & Warnings: Patients receiving immunosuppressive doses should avoid exposure to chickenpox or measles and seek immediate medical attention if exposed. Corticosteroids may mask infections and reduce resistance to new infections. Long-term use may cause cataracts, glaucoma, hypertension, electrolyte imbalance, and adrenal suppression. Live vaccines should generally be avoided during high-dose corticosteroid therapy.Use in Special Populations: Pediatric patients on prolonged corticosteroid therapy require close monitoring for growth and developmental suppression. Infants born to mothers receiving substantial corticosteroid doses during pregnancy should be monitored for adrenal insufficiency.Overdose Effects: Chronic overdose may lead to exaggerated corticosteroid-related adverse effects. Management is symptomatic, and gradual dose reduction is recommended whenever possible.Therapeutic Class: Glucocorticoids.Storage Conditions: Store in a cool and dry place, protected from light. Keep out of reach of children.