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Ziska Pharmaceuticals LtdProduct Description
Xiclav, which contains Cefuroxime axetil, is a second-generation cephalosporin antibiotic administered orally to treat a broad spectrum of bacterial infections, including respiratory tract infections, sinusitis, and uncomplicated urinary tract infections. As an ester prodrug, it is hydrolyzed in the intestinal mucosa and blood to release active cefuroxime, which exerts its bactericidal effect by binding to penicillin-binding proteins (PBPs) and inhibiting bacterial cell wall synthesis. It is particularly valued for its enhanced stability against many beta-lactamases compared to first-generation cephalosporins, allowing it to remain effective against organisms like Haemophilus influenzae and Moraxella catarrhalis. Clinical considerations include its better absorption when taken with food and the potential for cross-reactivity in patients with a history of penicillin allergy.
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