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Ebastine is a potent, long-acting second-generation antihistamine used primarily for the symptomatic relief of allergic rhinitis and chronic idiopathic urticaria. As a selective peripheral H1-receptor antagonist, it effectively prevents the action of histamine, thereby reducing symptoms such as sneezing, rhinorrhea, nasal itching, and skin hives. Upon administration, ebastine is rapidly converted into its active metabolite, carebastine, which provides sustained therapeutic effects with a once-daily dosing regimen. Unlike earlier antihistamines, ebastine exhibits minimal penetration of the blood-brain barrier, resulting in a low incidence of sedation or impaired psychomotor performance. It is generally well-tolerated, though some patients may experience mild side effects like dry mouth, headache, or drowsiness at higher doses.
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