Product Description

Indications: Nabu is indicated for the relief of signs and symptoms of osteoarthritis and rheumatoid arthritis. The decision to use this medicine should be based on a careful evaluation of benefits and risks, and it should be prescribed at the lowest effective dose for the shortest possible duration.

Pharmacology: Nabumetone is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. It acts by inhibiting prostaglandin synthesis, which plays a key role in inflammation and pain. Nabumetone is a prodrug that is metabolized in the liver to its active form, 6-methoxy-2-naphthylacetic acid (6-MNA), a potent inhibitor of prostaglandin production.

Dosage & Administration: The usual starting dose is 1000 mg once daily, taken with or without food. Depending on patient response, the dose may be increased to 1500–2000 mg daily, administered either as a single dose or in divided doses. Doses above 2000 mg per day are not recommended. For dispersible tablets, mix one tablet in a glass (250 ml) of water and consume immediately. In patients with moderate renal impairment, the starting dose should not exceed 750 mg daily, and in severe impairment, 500 mg daily. Dose adjustments may be made cautiously with monitoring. Safety in pediatric patients has not been established.

Interaction: Concomitant use with ACE inhibitors may reduce their antihypertensive effect. Caution is advised when used together.

Contraindications: Contraindicated in patients with hypersensitivity to nabumetone or any of its components. It should not be used in patients with a history of asthma, urticaria, or allergic reactions after taking aspirin or other NSAIDs. It is also contraindicated for pain management in the peri-operative period of coronary artery bypass graft (CABG) surgery.

Side Effects: Gastrointestinal effects include nausea, vomiting, abdominal pain, diarrhea, constipation, dyspepsia, and gastritis. Central nervous system effects may include headache, dizziness, fatigue, insomnia, nervousness, and drowsiness. Other reactions include rash, pruritus, tinnitus, increased sweating, and edema.

Pregnancy & Lactation: Classified as pregnancy category C. It should be used during pregnancy only if clearly necessary and is not recommended during the third trimester due to risk of fetal cardiovascular effects. It is also not recommended for use during breastfeeding due to potential adverse effects on the infant.

Precautions & Warnings: Long-term use of NSAIDs may lead to renal complications including reduced renal blood flow and renal failure, especially in high-risk patients such as those with renal impairment, heart failure, liver disease, or those on diuretics. Elderly patients are also at higher risk. Discontinuation usually reverses renal effects.

Overdose Effects: Symptoms of overdose may include drowsiness, nausea, vomiting, and abdominal pain. In severe cases, gastrointestinal bleeding, hypertension, renal failure, respiratory depression, or coma may occur. Management is supportive and symptomatic. Activated charcoal or gastric lavage may be considered if taken within a short time. There is no specific antidote, and dialysis is not effective due to high protein binding.

Therapeutic Class: Non-steroidal anti-inflammatory drugs (NSAIDs); Drugs for osteoarthritis and rheumatoid arthritis

Storage Conditions: Store below 30°C in a cool and dry place, protected from light and moisture. Keep out of reach of children.