Product Description

Here is a summary of the provided information regarding Symbion (Inhaler & Inhalation Capsule), organized by key clinical and practical categories:Indications & CompositionIndications:Asthma: Treatment in patients 12 years and older (not for acute bronchospasm relief).COPD: Twice-daily maintenance treatment of airflow obstruction in chronic obstructive pulmonary disease, including chronic bronchitis and emphysema.Composition: A fixed-dose combination of Budesonide BP (a glucocorticosteroid with anti-inflammatory action) and Formoterol Fumarate Dihydrate BP (a long-acting, selective $\beta_2$-adrenoceptor agonist with rapid onset).Dosage & AdministrationAsthma Inhaler (Adults/Adolescents $\ge$ 12 years):Maintenance: 1 puff twice daily or 2 puffs once daily (up to 2 puffs twice daily for higher strengths).Reliever: 1 additional puff as needed (max 6 puffs on any single occasion).Asthma Inhalation Capsule (Maintenance & Reliever Therapy):Adults/Adolescents ($\ge$ 12 years): Maintenance dose twice daily; 1 additional capsule as needed for symptoms (max 6 per occasion, normally $\le$ 8 daily, up to 12 temporarily).Children (4+ years): Maintenance dose once daily; 1 additional capsule as needed (max 4 per occasion, normally $\le$ 4 daily, up to 8 temporarily).COPD Inhalation Capsule (Adults $\ge$ 40 years):200 strength: 2 capsules twice daily (max 4 daily).400 strength: 1 capsule twice daily (max 2 daily).Inhaler Technique Steps:Remove cap and shake vigorously (at least 6 times).Breathe out fully, hold upright, and place mouthpiece between teeth with lips closed around it.Inhale deeply and slowly while pressing down firmly on the canister.Remove inhaler and hold breath for at least 10 seconds.Wait 1 minute if a second puff is needed; rinse mouth with water after treatment.Contraindications, Interactions & WarningsContraindications: Primary treatment of status asthmaticus or acute asthma/COPD episodes requiring intensive measures; hypersensitivity to any ingredients.Drug Interactions: Avoid strong CYP3A4 inhibitors (e.g., ritonavir). Use with caution alongside MAOIs, tricyclic antidepressants, beta-blockers (can block bronchodilation and cause severe bronchospasm), and diuretics (risk of hypokalemia).Precautions & Warnings: Use with caution in patients with diabetes, thyrotoxicosis, severe cardiovascular disorders, hypertension, or glaucoma. Discontinue immediately if paradoxical bronchospasm occurs. Regular monitoring of growth is recommended for pediatric patients on long-term treatment.Side Effects, Pregnancy & OverdoseSide Effects:Formoterol: Common include tremor, palpitations, and headache.Budesonide: Hoarseness, oropharyngeal candida infection, throat irritation, and mild immunosuppression.Pregnancy & Lactation: Budesonide passes into breast milk, but therapeutic doses are not expected to harm the infant. Use during breastfeeding only if expected benefits outweigh risks.Overdose Effects: Manifests mainly via $\beta_2$ agonist effects (tremor, headache, tachycardia, hypokalaemia, hyperglycemia). Chronic excessive budesonide use may lead to systemic glucocorticosteroid effects (hypercorticism and adrenal suppression).Storage ConditionsStore at or below 25°C, protected from light and moisture.Inhalation capsules must not be swallowed; use exclusively with the inhalation device and remove from the blister pack only immediately prior to use. Keep out of reach of children.রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন (Take medicine according to the registered physician's advice).