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200 Metered doses
Square Pharmaceuticals PLCProduct Description
The combination of Salbutamol (also known as Albuterol) and Ipratropium Bromide is a potent bronchodilator therapy used primarily for the management of chronic obstructive pulmonary disease (COPD) and acute asthma exacerbations. This combination utilizes a synergistic, dual-mechanism approach to reverse airflow obstruction by targeting different pathways in the autonomic nervous system. Salbutamol is a short-acting beta2-adrenergic agonist (SABA) that binds to receptors on airway smooth muscle, stimulating adenylate cyclase to increase cyclic AMP levels, which leads to rapid muscle relaxation and immediate bronchodilation. Complementing this, Ipratropium is a short-acting muscarinic antagonist (SAMA) that blocks M3 cholinergic receptors, inhibiting the bronchoconstrictive effects of acetylcholine released from the vagus nerve. By simultaneously stimulating the sympathetic "relax" response and blocking the parasympathetic "constrict" response, this dual therapy provides superior and more prolonged improvement in Forced Expiratory Volume (FEV1) compared to either agent used alone. Typically administered via a pressurized metered-dose inhaler or nebulizer, it is highly effective in relieving symptoms of dyspnea and wheezing. While generally safe, patients may experience side effects such as tachycardia, tremors, or dry mouth, and caution is advised for those with narrow-angle glaucoma or bladder neck obstruction due to the anticholinergic properties of Ipratropium.
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